NFL betting guide: Expert 2022 Week 13 NFL picks, predictions, odds & best bets

Cincinnati Bengals wide receiver Ja'Marr Chase (1) reacts after moving the ball forward against the Pittsburgh Steelers in the first half at Paycor Stadium.
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Phil Agius

NFL

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I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email contact@pickswise.com.
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Welcome to the Pickswise NFL Week 13 betting guide! There have been a few slates this season that were somewhat lacking in big-ticket matchups, but there’s no shortage of interest on this week’s schedule.

The Bills have already bagged a win over the Patriots on TNF and the early slate on Sunday brings plenty of intrigue. We will find out if Packers QB Aaron Rodgers is still the official owner of the Bears, Mike White and the upstart Jets make interesting opponents for the Vikings, there’s a high-stakes NFC East clash between the Commanders and Giants while divisional leaders the Eagles face a tough test from the Titans. Then there’s Deshaun Watson making his Browns debut after his 11-game suspension against his former team in Houston.

The late afternoon slate has some tasty matchups too, with Dolphins vs 49ers, Chargers vs Raiders and Chiefs vs Bengals in a rematch of the AFC Championship game before the Colts take on the Cowboys on Sunday Night Football.

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL Sunday — and for Monday night’s Saints vs Buccaneers game. Don’t forget to check out our great NFL predictions for every game on the Week 13 slate.

NFL Week 13 picks

  • NFL picks against the spread and total for EVERY Week 13 game – we were 22-10 on sides and totals in Week 12 
  • NFL best bets – we have a 41-26 record on our 3-star plays this season 
  • NFL parlays

NFL Week 13 expert betting picks and predictions

NFL Week 13 prop bets

NFL Week 13 Promo Codes

Find all the latest Sportsbook Promo Codes and Bonuses for NFL Week 13, including sportsbooks live in your state.

NFL Week 13 big-game predictions

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