College Football Week 5 Betting: Odds, Picks & Best Bets

The college football season continues with another huge slate of action on Saturday for Week 5. Iowa looks to back up its big win over Michigan at the Big House last week as the Hawkeyes host Ohio State in the standout matchup of the week. Here at Pickswise, we've got you covered with our expert college football picks and CFB predictions for 50 games on Saturday! On top of that, we have our college football expert’s best bets of the day, along with our CFB parlays to help you bet better across the NCAAF action.

College Football Week 5 Best Bets

• CFB Week 5 Best Bets - college football expert Sam Avellone gives his three top plays for Saturday, looking to add to our team's 18-10 record on CFB best bets

College Football Week 5 Parlays

• College Football Week 5 Saturday Parlay - after a parlay win last Saturday and another this past Thursday, check out our Saturday CFB parlay picks for this week

College Football Week 5 Player Props

• CFB Week 5 Player Props - Sam Avellone is 10-5 with his best CFB player prop bets so far this season. Lock in his top picks for Saturday's action
• CFB Week 5 Anytime TD Scorer Best Bets - Ricky Dimon is on an 8-4 run with his picks to find the end zone! Check out his CFB predictions for Saturday

College Football Week 5 Picks

Check out our expert college football predictions for the biggest games in Week 5 below:

• Ohio State vs Iowa prediction
• Michigan vs Minnesota prediction
• Alabama vs Mississippi State prediction
• West Virginia vs Iowa State prediction
• Notre Dame vs North Carolina prediction
• Navy vs Air Force prediction
• Michigan State vs Wisconsin prediction
• Vanderbilt vs Georgia prediction
• Auburn vs Tennessee prediction
• Florida vs Missouri prediction
• Virginia vs Florida State prediction
• Louisville vs NC State prediction
• Kentucky vs South Carolina prediction
• Purdue vs Illinois prediction
• Arkansas vs Texas A&M prediction
• Texas Tech vs Colorado prediction
• Miami vs Clemson prediction
• Washington vs USC prediction
• Indiana vs Rutgers prediction