Andrew Ortenberg
Show Bio
Welcome to the Pickswise NFL Week 16 betting guide. Our experts have done the research so you have everything you need to beat your book below! The 2021 NFL season will have its 16th full slate today, and this is your one-stop shop for all the info you need to inform your wagering.
NFL Week 16 picks
Pickswise Playbook
Make sure you check out Pickswise Playbook, our weekly NFL betting show with Chris Rose, Ross Tucker, and Jared Smith as they look to make your next bet better! Out every Thursday.
Week 16 betting articles
- Week 16 survivor pool picks
- Week 16 mega parlay (+1515 odds!) – We hit the mega in Week 11 at 18/1 AND Week 13 at 12/1, let’s make it three of six!
- This week’s hottest betting trends
- Week 16 millionaire parlay
- Jared Smith’s NFL Week 16 best bets
- Andrew Ortenberg’s best prop bets for the Week 16 NFL slate
- Man vs Machine: Pickswise expert vs the computer model Week 16
- Prop Bet Guy’s best prop bets for the Week 16 slate (scroll down to NFL!)
- The Dog House – the best NFL underdog plays for Week 16
- Week 16 anytime touchdown scorer prop bets
Week 16 big game same game parlays
We have same game parlays for every single NFL game, which you can find in our NFL news tab, but here are a select few from the biggest games of Week 16:
- Baltimore Ravens vs Cincinnati Bengals same game parlay (+855 odds!)
- Tampa Bay Buccaneers vs Carolina Panthers same game parlay (+4946 odds!)
- Buffalo Bills vs New England Patriots same game parlay (+1691 odds!)
- Los Angeles Rams vs Minnesota Vikings same game parlay (+740 odds!)
- Chicago Bears vs Seattle Seahawks same game parlay (+1118 odds!)
Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.
