College Football Week 10 Betting: Odds, Picks & Best Bets

Week 10 of the 2026 college football season has arrived, and we have just four more chaotic Saturdays before the regular season wraps up. The end is in sight, but the College Football Playoff picture has never been muddier. Top-ranked teams are losing all over the place, and it's hard to gauge who truly is the cream of the crop. However, a crunch matchup between #1-ranked Miami and contender Notre Dame could go a long way to determining those end-of-season rankings.

Here at Pickswise, we've got you covered with our expert college football picks for more than 50 games on Saturday! On top of that, we have our college football expert’s best bets of the day, along with our CFB parlays to help you bet better across the NCAAF action.

College Football Best Bets for Week 10

• CFB Week 10 Best Bets - college football expert Sam Avellone gives his three top plays for Saturday, looking to add to our team's 35-20 record on CFB best bets

College Football Parlays for Week 10

• College Football Week 10 Saturday Parlay - we've cashed 13 parlays this season for +23.57 units! Check out this Saturday's picks

College Football Player Props for Week 10

• CFB Week 10 Player Props - Don't miss Sam Avellone's best CFB player prop bets of the day - he's 16-11 this season!
• CFB Week 10 Anytime TD Scorer Best Bets - Ricky Dimon's on a 6-3 run over the last three weeks on his predictions to find the end zone

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College Football Picks for Week 10

Check out our expert college football predictions for the biggest games in Week 10 below:

• Miami vs Notre Dame prediction
• Texas vs Missouri prediction
• Oregon vs Ohio State prediction
• Georgia vs Ole Miss prediction
• Florida State vs Boston College prediction
• North Carolina vs UConn prediction
• BYU vs Utah prediction
• UCLA vs Minnesota prediction
• Oklahoma State vs Kansas State prediction
• Texas A&M vs South Carolina prediction
• Penn State vs Washington prediction
• Rutgers vs Wisconsin prediction
• Kentucky vs Tennessee prediction
• Air Force vs Army prediction
• Michigan State vs Michigan prediction
• Oklahoma vs Florida prediction
• West Virginia vs Texas Tech prediction