NFL

NFL Week 6 Sunday Betting Guide: Picks, Odds & Predictions

UpdatedOct 18, 2026

Reading time2 min

The 2026 NFL season pulls into Week 6, and the waters continue to be murky as far as a standout Super Bowl contender is concerned. The 49ers are 5-0 and putting forth the best case, while preseason favorites the Rams have stuttered to a 2-3 start and the Bills only just edged that contest to move to 4-1. With things still seemingly wide open, this Sunday presents 26 teams with a chance to prove their credentials once again.

To make sure you're all set for the NFL Week 6 Sunday slate, our expert handicappers here at Pickswise have analyzed all 12 games and delivered their NFL picks and NFL predictions on the side and total for every matchup! In addition, we also have our NFL best bets for Sunday, where we're currently riding a 10-3 hot streak, and you can also catch our NFL parlays for today.

Welcome Bonus

UnderdogPlay $5, Get $100

Trading involves risk, including total loss on positions. Content is promotional and not a recommendation to trade. Promotion issued by affiliate. Terms apply. Must be 18+ (19+ in AL, NE; 19+ in CO for some games; 21+ in AZ, MA, and VA) and present in a state where Underdog Fantasy operates. Terms apply. See assets.underdogfantasy.com/web/PlayandGetTerms_DFS_.html for details. Offer not valid in MD, MI,NY, OH, and PA. Concerned with your play? Call 1-800-GAMBLER or visit www.ncpgambling.org; NY: Call the 24/7 HOPEline at 1-877-8-HOPENY or Text HOPENY (467369)

$100Claim Offer

NFL Week 6 Best Bets

NFL Week 6 Best Bets - get four of our expert handicappers' top plays for Sunday!

NFL Week 6 Parlays

NFL Week 6 Parlay - aim for the big payout on Sunday with our expert's NFL parlay picks
Cowboys vs Packers SNF Same Game Parlay - after cashing our Steelers vs Browns SGP at +750 and Falcons vs Saints SGP at +650 in Week 4, and our Bills vs Rams SGP at +700 in Week 5, don't miss our expert's best Sunday Night Football SGP!

NFL Week 6 Player Props

Best NFL Week 6 player props - find out props expert JutPicks' top plays for Sunday
NFL Week 6 anytime touchdown scorer best bets - target these players to score a TD on Sunday afternoon's mega slate
Cowboys vs Packers TD scorer best bets - our expert has tons of primetime TD scorers recently, including at +400, +330, +300 and +250! Get his players to find the end zone on SNF
Cowboys vs Packers player props - we're on an 8-2 run with our SNF player props so far this season!

Welcome Bonus