NFL betting guide: Expert 2022 Week 4 NFL picks, predictions, odds & best bets

Kansas City Chiefs quarterback Patrick Mahomes (15) drops back to pass against the Tampa Bay Buccaneers during the second half at Raymond James Stadium.
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Phil Agius


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I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email
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Welcome to the Pickswise NFL Week 4 betting guide. Amazingly, the 4th Sunday of the 2022 NFL season arrives with just one remaining unbeaten team in the 3-0 Philadelphia Eagles and only the Las Vegas Raiders at 0-3 (although the 0-2-1 Texans are also winless). Every other team already has entries in both the W and L columns, and if what we’ve seen so far holds true then we can expect more huge turnarounds and crazy finishes on Sunday’s slate.

Week 4 is headlined by the rerun of Super Bowl LV as the Chiefs visit the Buccaneers on Sunday Night Football, while the earlier games include some tasty divisional rivalries including Commanders vs Cowboys, Titans vs Colts and Broncos vs Raiders, plus an exciting AFC showdown between the Bills and Ravens.

It’s also the start of the international games, with the Vikings taking on the Saints at Tottenham Hotspur Stadium in London, which means the extended Sunday slate starts at 9:30am ET and rolls all day through to Sunday Night Football!

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL Sunday — and Monday night’s Rams vs 49ers game too!

Don’t forget to check out our great new game previews, which now include prop picks, projections, trends and same game parlays!

Our handicappers have made a fantastic start to the 2022 season and our 3-star Best Bets are 14-5 on the year. Also, be sure to check out our EXCLUSIVE TD scorer odds boost for Week 4 from DraftKings Sportsbook.

NFL Week 4 picks

  • NFL picks against the spread and total for EVERY Week 4 game
  • NFL best bets – we have a 14-5 record on our 3-star plays this season and FOUR picks this week!
  • NFL parlays

NFL Week 4 expert betting picks and predictions

NFL Week 4 prop bets

NFL Week 4 Promo Codes

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Find all the latest Sportsbook Promo Codes and bonuses for NFL Week 4, including sportsbooks live in your state.

NFL Week 4 big-game predictions

Watch Pickswise Playbook!

Our weekly NFL show Pickswise Playbook, presented by Superbook Sports, is hosted by Lauren Jbara and Jared Smith and features former NFL player Tank Williams as this week’s guest.

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

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